The 30-year-old right-hander has 2,163 strikeouts, which is 59th all time. Hernandez is ranked third among active players in strikeouts.
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Hernandez recorded more than 200 strikeouts a season from 2009 to 2014, including a career-high 248 strikeouts in the final year of that stretch.
The Mariners grabbed an early 1-0 lead over the Angels on Leonys Martin’s second-inning sacrifice fly to score Franklin Gutierrez.
Hernandez is 1-1 with a 1.00 ERA and 21 strikeouts so far this season and has a career mark of 144-102.
